A recombined fusion protein SP5.2/tTF induce thrombosis in tumor blood vessel
نویسندگان
چکیده
منابع مشابه
Tumor blood vessel visualization.
Significant advances have been made in understanding the role of tumor angiogenesis and its influence on tumor progression in cancer. Based on this knowledge, a series of inhibitors of angiogenesis have been developed and evaluated in preclinical and clinical trials. Since detailed information of tumor progression in response to therapy is important to assess the efficacy of anti-tumor treatmen...
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Tissue Factor (TF) is a cell membrane receptor protein that is the initiator of the extrinsic pathway of the blood coagulation cascade and normally released from damaged tissues. By substituting the attachment site with a tumor delivery agent, this potent thrombogenic protein in its truncated form (tTF) can be targeted to the tumor where it can initiate clotting, thereby occluding the tumor’s b...
متن کاملComparison of three different targeted tissue factor fusion proteins for inducing tumor vessel thrombosis.
Tissue Factor (TF) is a cell membrane receptor protein that is the initiator of the extrinsic pathway of the blood coagulation cascade and normally released from damaged tissues. By substituting the attachment site with a tumor delivery agent, this potent thrombogenic protein in its truncated form (tTF) can be targeted to the tumor where it can initiate clotting, thereby occluding the tumor's b...
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Splenogonadal fusion is a rare congenital malformation whereby the splenic tissue is found attached or surrounded by the testis, and presents in both continuous and discontinuous forms. Splenogonadal fusion may be misinterpreted as a primary malignant testicular or an adenomatoid tumor. Knowledge about the existence of such an entity is essential in order to preserve the testis during surgical ...
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Internal Medicine, I would not have been able to pursue the work that is presented here. Thank you, Dave, for not only hiring me as an undergraduate student, but for allowing me to continue on as a graduate student in your lab. And thank you, Steve, for allowing me to finish my graduate work in your lab and providing so much guidance over the last nine months. I also need to thank Dr. Edward Sa...
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ژورنال
عنوان ژورنال: Neoplasma
سال: 2015
ISSN: 1338-4317
DOI: 10.4149/neo_2015_064